This handout is based on a webinar on March 2021 by Drs. Alexa Martin-Storey, Université de Sherbrooke, and Melanie Dirks, McGill University. It discusses what recent research tells us about adolescent well-being during COVID-19, along with risk and protective factors associated with (1) following COVID-19 guidelines; (2) Mental health and psychosocial functioning; (3) Maintaining healthy relationships.